(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid

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Chemical Name:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid
CAS No.:102650-95-3
Molecular Formula:C₂₆H₂₇N₉O₆
Molecular Weight:561.557
Hs Code.:

Synonyms:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid

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Chemical Property of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid

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Technology Process of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid

There total 3 articles about (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 102650-93-1
(S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid

: 102650-95-3
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid

Guidance literature:: With tris(trifluoro acetyloxy)borane; In trifluoroacetic acid; 1.) 0 deg C, 15 min, 2.) RT, 3 h;
DOI:10.1021/jm00159a023

Reference yield:

: 89043-75-4
4-amino-4-deoxy-N¹⁰-formylpteroic acid

: 102650-95-3
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / i-BuOCOCl, Et₃N / dimethylformamide; H₂O / 75 h / Ambient temperature

2: 93 percent / 0.25 N NaOH, 10percent AcOH / methanol / 72 h / 25 °C

3: 79 percent / 0.5 M boron tris(trifluoroacetate) / trifluoroacetic acid / 1.) 0 deg C, 15 min, 2.) RT, 3 h

With sodium hydroxide; tris(trifluoro acetyloxy)borane; acetic acid; triethylamine; isobutyl chloroformate; In methanol; water; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/jm00159a023

Reference yield:

: 102651-02-5
(S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester

: 102650-95-3
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / 0.25 N NaOH, 10percent AcOH / methanol / 72 h / 25 °C

2: 79 percent / 0.5 M boron tris(trifluoroacetate) / trifluoroacetic acid / 1.) 0 deg C, 15 min, 2.) RT, 3 h

With sodium hydroxide; tris(trifluoro acetyloxy)borane; acetic acid; In methanol; trifluoroacetic acid;
DOI:10.1021/jm00159a023