((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate

Base Information

Chemical Name:((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate
CAS No.:1438281-03-8
Molecular Formula:C₂₉H₂₅N₃O₁₀
Molecular Weight:575.532
Hs Code.:

Synonyms:((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate

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Chemical Property of ((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate

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Technology Process of ((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate

There total 3 articles about ((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1438281-02-7
(3aS,5R,6S,6aR)-6-hydroxy-5-(hydroxymethyl)-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-2-one

: 122-04-3
4-nitro-benzoyl chloride

: 1438281-03-8
((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c3ob27390c

Reference yield:

: 182370-58-7
(R)-1-((S)-1-phenylethyl)aziridine-2-carbaldehyde

: 1438281-03-8
((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc dibromide / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / tetrahydrofuran; water / 15 h / Inert atmosphere

3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; zinc dibromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c3ob27390c

Reference yield:

: 1438281-01-6
(R)-5-((S)-hydroxy((R)-1-((S)-1-phenylethyl)aziridin-2-yl)methyl)-furan-2(5H)-one

: 1438281-03-8
((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / tetrahydrofuran; water / 15 h / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c3ob27390c