1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

Base Information

Chemical Name:1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil
CAS No.:1275611-07-8
Molecular Formula:C₂₀H₂₆N₂O₁₃S₃
Molecular Weight:598.63
Hs Code.:

Synonyms:1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

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Chemical Property of 1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

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Technology Process of 1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

There total 3 articles about 1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1275611-06-7
1-[3-O-benzyl-5-O-(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

: 124-63-0
methanesulfonyl chloride

: 1275611-07-8
1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

Guidance literature:: With pyridine; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1275611-05-6
1-[2-O-acetyl-3-O-benzyl-5-O-(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

: 1275611-07-8
1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 24 h / 20 °C

2: pyridine / 4 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; In methanol;

Reference yield:

: 410076-93-6
3-O-benzyl-1,2-di-O-acetyl-5-O-(methylsulfonyl)-4-C-(methylsulfonyloxymethyl)-α,β-L-threo-pentofuranose

: 1275611-07-8
1-[3-O-benzyl-2,5-O-bis(methanesulfonyl)-4-C-(methanesulfonyloxymethyl)-α-L-threo-pentofuranosyl]uracil

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / Reflux; Inert atmosphere

1.2: 28 h / 20 °C / Reflux; Inert atmosphere

2.1: hydrogenchloride / methanol / 24 h / 20 °C

3.1: pyridine / 4 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; N,O-bis-(trimethylsilyl)-acetamide; In methanol; acetonitrile;