(2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

Base Information

Chemical Name:(2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine
CAS No.:782496-03-1
Molecular Formula:C₂₇H₃₉NO₄Si
Molecular Weight:469.696
Hs Code.:

Synonyms:(2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

Suppliers and Price of (2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

There total 9 articles about (2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141293-28-9
N-(tert-butoxycarbonyl)-2-[(tert-butyldimethylsilyl)oxy]pyrrole

: 782496-03-1
(2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / SnCl₄ / diethyl ether / 3 h / -80 °C

2: 90 percent / H₂; NaOAc / Pd/C / tetrahydrofuran / 24 h / 20 °C

3: AcOH; water / 8 h / 50 °C

4: NaIO₄ / CH₂Cl₂; H₂O / 0.25 h

5: 5.2 g / NaBH₄ / methanol / -30 - -15 °C

6: 83 percent / imidazole / dimethylformamide / 18 h / 20 °C

7: LiEt₃BH / tetrahydrofuran / 3 h / -78 °C

8: BF₃*OEt₂ / diethyl ether / 0.5 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; boron trifluoride diethyl etherate; water; hydrogen; sodium acetate; tin(IV) chloride; lithium triethylborohydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 1: Mukaiyama aldolization / 2: Catalytic hydrogenation / 3: Hydrolysis / 4: Oxidation / 5: Reduction / 6: Substitution / 7: Reduction / 8: Alkylation;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1395::AID-EJOC1395>3.0.CO;2-T

Reference yield:

: 141393-87-5
4-<(tert-butoxycarbonyl)amino>-6,7-O-isopropylidene-2,3,4-trideoxy-L-arabino-hept-2-enonic acid 1,4-lactam

: 782496-03-1
(2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / H₂; NaOAc / Pd/C / tetrahydrofuran / 24 h / 20 °C

2: AcOH; water / 8 h / 50 °C

3: NaIO₄ / CH₂Cl₂; H₂O / 0.25 h

4: 5.2 g / NaBH₄ / methanol / -30 - -15 °C

5: 83 percent / imidazole / dimethylformamide / 18 h / 20 °C

6: LiEt₃BH / tetrahydrofuran / 3 h / -78 °C

7: BF₃*OEt₂ / diethyl ether / 0.5 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; boron trifluoride diethyl etherate; water; hydrogen; sodium acetate; lithium triethylborohydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 1: Catalytic hydrogenation / 2: Hydrolysis / 3: Oxidation / 4: Reduction / 5: Substitution / 6: Reduction / 7: Alkylation;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1395::AID-EJOC1395>3.0.CO;2-T

Reference yield:

: 192389-43-8
(5S)-1-(benzyloxycarbonyl)-5-[(tert-butyldiphenylsilyl)oxymethyl]-2-hydroxypyrrolidine

: 149-73-5
trimethyl orthoformate

: (2R,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

: 782496-03-1
(2S,5S)-N-(tert-butoxycarbonyl)-5[(tert-butyldiphenylsilyl)oxymethyl]-2-methoxypyrrolidine

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at 20 ℃; for 0.5h; Title compound not separated from byproducts;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1395::AID-EJOC1395>3.0.CO;2-T