2-Fluoro-4,6-dimethoxybenzaldehyde

Base Information

• Chemical Name: 2-Fluoro-4,6-dimethoxybenzaldehyde
• CAS No.: 214492-73-6
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.167
• Hs Code.: 2913000090
• European Community (EC) Number: 895-852-0
• Mol file: 214492-73-6.mol

Synonyms:2-fluoro-4,6-dimethoxybenzaldehyde;214492-73-6;2-Fluoro-4,6-diMethoxy-benzaldehyde;SCHEMBL1645590;MRXOVFKDPODHDQ-UHFFFAOYSA-N;AMY37339;MFCD18906188;CS-W000047;D77527;EN300-6739566;Z1222424383

Chemical Property of 2-Fluoro-4,6-dimethoxybenzaldehyde

Chemical Property:

• Boiling Point: 270.2±35.0 °C(Predicted)
• Density: 1.201±0.06 g/cm3(Predicted)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 184.05357231
• Heavy Atom Count: 13
• Complexity: 174

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4,6-dimethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)F)C=O)OC

Technology Process of 2-Fluoro-4,6-dimethoxybenzaldehyde

There total 4 articles about 2-Fluoro-4,6-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

3,5-dimethoxyfluorobenzene (52189-63-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-fluoro-4,6-dimethoxybenzaldehyde (214492-73-6)

Guidance literature:

With trichlorophosphate; at 0 - 20 ℃;

Reference yield:

3,5-dimethoxyfluorobenzene (52189-63-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-fluoro-4,6-dimethoxybenzaldehyde (214492-73-6) + 4-fluoro-2,6-dimethoxybenzaldehyde (139549-11-4)

Guidance literature:

With trichlorophosphate; at -5 - 60 ℃; Overall yield = 46 percent; Inert atmosphere;

DOI:10.1002/anie.201910059

Reference yield:

3,5-dimethoxyfluorobenzene (52189-63-6) + N-methyl-N-phenylformamide (93-61-8) → 2-fluoro-4,6-dimethoxybenzaldehyde (214492-73-6) + 4-fluoro-2,6-dimethoxybenzaldehyde (139549-11-4)

Guidance literature:

With trichlorophosphate; Yield given. Yields of byproduct given; -5 deg C, then room temp., 1.5 h, then 60 deg C, 2 h;

DOI:10.1002/(SICI)1522-2675(19980909)81:9<1596::AID-HLCA1596>3.0.CO;2-F

upstream raw materials:

3,5-dimethoxyfluorobenzene

N-methyl-N-phenylformamide

3.5-dimethoxyaniline

N,N-dimethyl-formamide

Downstream raw materials:

2,4-dihydroxy-6-fluorobenzaldehyde

2-fluoro-4-(tetrahydro-2H-pyran-2-yloxy)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

3-fluoro-2-formyl-5-(tetrahydro-2H-pyran-2-yloxy)phenyltrifluoromethanesulfonate

2-fluoro-6-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy) benzaldehyde

Refernces

• 1、 -. "TRISUBSTITUTED BORON-CONTAINING MOLECULES". . . Retrieved 2011/02/24.