trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide

Base Information

Chemical Name:trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide
CAS No.:901765-35-3
Molecular Formula:C₁₈H₁₉FN₄O₂S
Molecular Weight:374.439
Hs Code.:

Synonyms:trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide

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Technology Process of trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide

There total 4 articles about trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: C₁₈H₁₉FN₄O₃S

: 901765-35-3
trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide

Guidance literature:: With carbon monoxide; gold; In water; toluene; at 100 ℃; for 5h; under 6000 - 7000 Torr; Autoclave;

Reference yield: 81.0%

: 7605-28-9
2-(phenylsulfonyl)acetonitrile

: 147118-37-4
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

: 901765-35-3
trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 8.5h;

Reference yield: 70.0%

: 894787-92-9
N-(5-bromo-4-(4-fluorophenyl)-6-isopropylpyriinidin-2-yl)-N-methylmethanesulfonamide

: 107-13-1,25014-41-9
acrylonitrile

: 901765-35-3
trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide

Guidance literature:: With N-Methyldicyclohexylamine; tetrabutylammomium bromide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In toluene; at 50 ℃; for 7.08333h;