Technology Process of 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepine-8-carbaldehyde 1,1-dioxide
There total 18 articles about 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepine-8-carbaldehyde 1,1-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 25 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: trifluorormethanesulfonic acid / dichloromethane / 49 h / 5 - 20 °C / Reflux
2.1: boron trichloride / dichloromethane / 0.5 h / 0 - 5 °C
2.2: 0.5 h / 10 °C
2.3: 0.5 h / 15 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C
3.2: 3 h / 60 °C
4.1: diphenylether / 4.5 h / 215 °C
5.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux
5.2: 15 h / 85 °C
6.1: citric acid / toluene / 50 h / 130 °C / Reflux
7.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C
8.2: 0.5 h
9.1: borane-THF / tetrahydrofuran / 2 h / 25 °C
10.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C
10.2: 1 h / pH 12 / Cooling with ice
11.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C
With
lithium aluminium tetrahydride; borane-THF; trifluorormethanesulfonic acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; dihydrogen peroxide; boron trichloride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; citric acid; potassium hydroxide;
palladium diacetate;
In
tetrahydrofuran; diphenylether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: trifluorormethanesulfonic acid / dichloromethane / 49 h / 5 - 20 °C / Reflux
2.1: boron trichloride / dichloromethane / 0.5 h / 0 - 5 °C
2.2: 0.5 h / 10 °C
2.3: 0.5 h / 15 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C
3.2: 3 h / 60 °C
4.1: diphenylether / 4.5 h / 215 °C
5.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux
5.2: 15 h / 85 °C
6.1: citric acid / toluene / 50 h / 130 °C / Reflux
7.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C
8.2: 0.5 h
9.1: borane-THF / tetrahydrofuran / 2 h / 25 °C
10.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C
10.2: 1 h / pH 12 / Cooling with ice
11.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C
With
lithium aluminium tetrahydride; borane-THF; trifluorormethanesulfonic acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; dihydrogen peroxide; boron trichloride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; citric acid; potassium hydroxide;
palladium diacetate;
In
tetrahydrofuran; diphenylether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
![[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol](/Databaselist/images/loading.webp)
