(2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid

Base Information

Chemical Name:(2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid
CAS No.:1404090-60-3
Molecular Formula:C₃₆H₃₉NO₅Si
Molecular Weight:593.795
Hs Code.:

Synonyms:(2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid

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Chemical Property of (2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid

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Technology Process of (2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid

There total 6 articles about (2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

: 1404089-95-7
benzyl(2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoate

: 1404090-60-3
(2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid

Guidance literature:: With rosenmund catalyst; hydrogen; In ethanol; water; isopropyl alcohol; at 30 - 35 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: C₂₈H₃₅NO₃Si

: 1404090-60-3
(2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water / 0.25 h / 20 °C

2: hydrogen; rosenmund catalyst / ethanol; water; isopropyl alcohol / 1.5 h / 30 - 35 °C / Inert atmosphere

With rosenmund catalyst; hydrogen; sodium hydrogencarbonate; In ethanol; water; isopropyl alcohol;

Reference yield:

: Boc-Glu-OBzl

: 1404090-60-3
(2S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / -15 - -10 °C

1.2: 0.83 h / 0 - 25 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0.42 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h

4.1: sodium hydrogencarbonate / water / 0.25 h / 20 °C

5.1: hydrogen; rosenmund catalyst / ethanol; water; isopropyl alcohol / 1.5 h / 30 - 35 °C / Inert atmosphere

With 1H-imidazole; rosenmund catalyst; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;