ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate

Base Information

• Chemical Name: ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate
• CAS No.: 1373823-01-8
• Molecular Formula: C₁₆H₂₁NO₄S
• Molecular Weight: 323.413
• Mol file: 1373823-01-8.mol

Synonyms:ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate

Chemical Property of ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate

There total 5 articles about ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 2-aminocyclohex-1-ene-1-carboxylate (1128-00-3) + p-toluenesulfonyl chloride (98-59-9) → ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate (1373823-01-8)

Guidance literature:

With pyridine; In dichloromethane; at 25 ℃; for 12h;

DOI:10.1039/c9gc03688a

Reference yield: 79.0%

4-toluenesulfonyl azide (941-55-9) + cyclohex-1-enecarboxylic acid ethyl ester (1617-22-7) → ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate (1373823-01-8)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium carbonate; acetic acid; silver(I) triflimide; In 1,2-dichloro-ethane; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201310544

Reference yield: 39.0%

toluene-4-sulfonamide (70-55-3) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl 2-((4-methylphenyl)sulfonamido)cyclohex-1-ene-1-carboxylate (1373823-01-8)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2012.03.035

upstream raw materials:

toluene-4-sulfonamide

ethyl 2-oxocyclohexane carboxylate

4-toluenesulfonyl azide

cyclohex-1-enecarboxylic acid ethyl ester

Downstream raw materials:

ethyl 2-(4-methylphenylsulfonamido)cyclohexanecarboxylate