Technology Process of (3S,3aR,4S,6S,6aS,8S,9R,9aR,9bS)-8-(tert-Butyl-diphenyl-silanyloxy)-3,3a-dihydroxy-4,6-bis-methoxymethoxy-3,6,9-trimethyl-decahydro-azuleno[4,5-b]furan-2-one
There total 26 articles about (3S,3aR,4S,6S,6aS,8S,9R,9aR,9bS)-8-(tert-Butyl-diphenyl-silanyloxy)-3,3a-dihydroxy-4,6-bis-methoxymethoxy-3,6,9-trimethyl-decahydro-azuleno[4,5-b]furan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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663605-98-9
(2S,3R,3aR,4S,5S,6S,8S,8aS)-2-(tert-Butyl-diphenyl-silanyloxy)-5-((R)-1,2-dihydroxy-1-methyl-ethyl)-6,8-bis-methoxymethoxy-3,8-dimethyl-decahydro-azulene-4,5-diol
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663605-99-0
(3S,3aR,4S,6S,6aS,8S,9R,9aR,9bS)-8-(tert-Butyl-diphenyl-silanyloxy)-3,3a-dihydroxy-4,6-bis-methoxymethoxy-3,6,9-trimethyl-decahydro-azuleno[4,5-b]furan-2-one
- Guidance literature:
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With
tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide;
In
acetonitrile;
at 20 ℃;
for 1.5h;
DOI:10.1002/chem.200700302
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663605-99-0
(3S,3aR,4S,6S,6aS,8S,9R,9aR,9bS)-8-(tert-Butyl-diphenyl-silanyloxy)-3,3a-dihydroxy-4,6-bis-methoxymethoxy-3,6,9-trimethyl-decahydro-azuleno[4,5-b]furan-2-one
- Guidance literature:
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Multi-step reaction with 5 steps
1: 2,6-dimethylpyridine; dmap / dichloromethane / 3 h / 20 °C
2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
3: Quinuclidine; osmium(VIII) oxide; potassium carbonate / potassium hexacyanoperferrate; methanesulfonamide / water; tert-butyl alcohol / 240 h / 20 °C
4: potassium carbonate / methanol / 1 h / 20 °C
5: tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C
With
Quinuclidine; 2,6-dimethylpyridine; dmap; osmium(VIII) oxide; tetrapropylammonium perruthennate; 4 A molecular sieve; potassium carbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine;
potassium hexacyanoperferrate; methanesulfonamide;
In
methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/chem.200700302
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663605-99-0
(3S,3aR,4S,6S,6aS,8S,9R,9aR,9bS)-8-(tert-Butyl-diphenyl-silanyloxy)-3,3a-dihydroxy-4,6-bis-methoxymethoxy-3,6,9-trimethyl-decahydro-azuleno[4,5-b]furan-2-one
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2: Quinuclidine; osmium(VIII) oxide; potassium carbonate / potassium hexacyanoperferrate; methanesulfonamide / water; tert-butyl alcohol / 240 h / 20 °C
3: potassium carbonate / methanol / 1 h / 20 °C
4: tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C
With
Quinuclidine; dmap; osmium(VIII) oxide; tetrapropylammonium perruthennate; 4 A molecular sieve; potassium carbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine;
potassium hexacyanoperferrate; methanesulfonamide;
In
methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/chem.200700302
