Technology Process of tert-butyl 4-((3,3-dimethylcyclobutyl)(7-fluoroquinolin-3-ylamino)methyl)benzoate
There total 7 articles about tert-butyl 4-((3,3-dimethylcyclobutyl)(7-fluoroquinolin-3-ylamino)methyl)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 65 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride / dichloromethane / 4 h / 20 °C
2.1: TurboGrignard / tetrahydrofuran / 2.25 h / -30 °C
2.2: 0.42 h / -30 - -20 °C
2.3: 4.08 h / -40 - 0 °C
3.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h
4.1: dichloromethane / 24 h / Reflux
5.1: sodium cyanoborohydride; ammonium acetate / methanol / 18 h / 60 °C
6.1: chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 65 °C
With
TurboGrignard; oxalyl dichloride; chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); ammonium acetate; sodium cyanoborohydride; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-benzyl-N,N,N-triethylammonium chloride / water; toluene / 16.25 h / 40 °C
2: chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 65 °C
With
chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); N-benzyl-N,N,N-triethylammonium chloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; water; toluene;
