1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane

Base Information

Chemical Name:1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane
CAS No.:864160-20-3
Molecular Formula:C₂₃H₃₅NOSi
Molecular Weight:369.623
Hs Code.:

Synonyms:1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane

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Chemical Property of 1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane

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Technology Process of 1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane

There total 7 articles about 1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 620600-27-3
1-(4-((tert-butyldimethylsilyl)oxy)phenyl)propan-2-one

: 103-67-3
benzyl-methyl-amine

: 864160-20-3
1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃; for 24h;
DOI:10.1248/cpb.53.684

Reference yield:

: 864160-19-0
2-(4-tert-butyldimethylsiloxyphenyl)propanol

: 864160-20-3
1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - -20 °C

2: 51 percent / HCl; NaBH₃CN / methanol / 24 h / 20 °C

With hydrogenchloride; oxalyl dichloride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; 1: Swern oxidation;
DOI:10.1248/cpb.53.684

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 864160-20-3
1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / imidazole / dimethylformamide / 0.5 h / 0 °C

2: 99 percent / LiAlH₄ / diethyl ether / 1.75 h / 20 °C

3: 3.59 g / pyridinium chlorochromate / CH₂Cl₂ / 5 h / 0 °C

4: 1.99 g / diethyl ether / 1 h / -78 °C

5: 83 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - -20 °C

6: 51 percent / HCl; NaBH₃CN / methanol / 24 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 5: Swern oxidation;
DOI:10.1248/cpb.53.684