1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL

Base Information

• Chemical Name: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL
• CAS No.: 53981-69-4
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Hs Code.: 2933290090
• Mol file: 53981-69-4.mol

Synonyms:Ketone,imidazol-2-yl methyl (7CI);1-(1H-Imidazol-2-yl)-1-ethanone;2-Acetylimidazole;2-Imidazolyl methyl ketone;

Chemical Property of 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL

Chemical Property:

• Vapor Pressure: 0.00727mmHg at 25°C
• Melting Point: 136-138℃
• Refractive Index: 1.535
• Boiling Point: 269.4 °C at 760 mmHg
• PKA: 11.11±0.10(Predicted)
• Flash Point: 120.8 °C
• PSA: 45.75000
• Density: 1.19 g/cm³
• LogP: 1.41430
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(1H-Imidazol-2-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL

There total 11 articles about 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 1-(diethoxymethyl)-1H-imidazole (61278-81-7) → 1-(1H-imidazol-2-yl)ethanone (53981-69-4)

Guidance literature:

1-(diethoxymethyl)-1H-imidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -55 - -35 ℃; for 0.25h;

N,N-dimethyl acetamide; In tetrahydrofuran; hexane; at 20 ℃; for 25.5833h;

Reference yield:

1-(1-tosyl-1H-imidazol-2-yl)ethan-1-one (875553-56-3) → 1-(1H-imidazol-2-yl)ethanone (53981-69-4)

Guidance literature:

With piperidine; In methanol; at 85 ℃; for 4h; Microwave irradiation; Inert atmosphere;

Reference yield:

methylmagnesium bromide (75-16-1) + 2-cyano imidazole (31722-49-3) → 1-(1H-imidazol-2-yl)ethanone (53981-69-4)

Guidance literature:

methylmagnesium bromide; 2-cyano imidazole; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

1-(1H-imidazol-2-yl)ethan-1-ol

N-Acetylimidazole

N,N-dimethyl acetamide

1-(diethoxymethyl)-1H-imidazole

Downstream raw materials:

dichlorodimethylbis(1-acetylimidazole)tin(IV)

4-methylimidazo[1,2-a]quinoxaline