Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)
• CAS No.: 92398-47-5
• Molecular Formula: C6H11 N O2 . Cl H
• Molecular Weight: 165.62
• Hs Code.: 2922499990
• Mol file: 92398-47-5.mol

Synonyms:Cyclobutanecarboxylicacid, 1-amino-, methyl ester, hydrochloride (9CI); 1-Aminocyclobutanecarboxylicacid methyl ester hydrochloride

Chemical Property of Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)

Chemical Property:

• Vapor Pressure: 0.194mmHg at 25°C
• Boiling Point: 206.8°C at 760 mmHg
• Flash Point: 78.9°C
• PSA: 52.32000
• LogP: 1.54310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

Methyl1-AminocyclobutanecarboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used as a primary and secondary intermediate for pharmaceutical and organic synthesis.

Technology Process of Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)

There total 5 articles about Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 1-aminocyclobutane-1-carboxylic acid (22264-50-2) → 1-aminocyclobutane-1-carboxylic acid methyl ester hydrochloride (92398-47-5)

Guidance literature:

With acetyl chloride; at 0 - 20 ℃; for 0.12h;

Reference yield: 98.0%

methanol (67-56-1) + 1-aminocyclobutanecarboxylic acid hydrochloride → 1-aminocyclobutane-1-carboxylic acid methyl ester hydrochloride (92398-47-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 65.0%

1-aminocyclobutanecarboxylic acid hydrochloride → 1-aminocyclobutane-1-carboxylic acid methyl ester hydrochloride (92398-47-5)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 65 ℃; for 4h;

DOI:10.1055/s-0034-1380434

upstream raw materials:

methanol

1-aminocyclobutane-1-carboxylic acid

1,3-diazaspiro[4.3]octane-2,4-dione

Downstream raw materials:

methyl 1-(2-nitrophenylsulfonamido)cyclobutanecarboxylate

1-(2-nitrophenylsulfonamido)cyclobutanecarboxylic acid

N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide

methyl 4-(1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamido)adamantane-1-carboxylate

Refernces

• 1、 -. "NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS". Page/Page column 80-81. . Retrieved 2017/02/24.
• 2、 Dobrydnev, Alexey V.,Popova, Maria V.,Saffon-Merceron, Nathalie,Listunov, Dymytrii,Volovenko, Yulian M.. "Synthesis of the First Representatives of Spiro-1λ6-isothiazolidine-1,1,4-triones". . p. 2523 - 2528. Retrieved 2015/09/01.