Technology Process of 4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide
There total 8 articles about 4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 4 h / 140 °C
2.1: ammonium hydroxide; ammonium acetate / 2 h / 80 °C
2.2: 72 h / 80 °C / pressure bottle
3.1: sulfuric acid / Inert atmosphere; Reflux
4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 90 °C
5.1: N-ethyl-N,N-diisopropylamine; sodium sulfate / acetonitrile / 0.17 h
5.2: 45 - 60 °C
5.3: 18 h / 60 °C / pressure vessel
With
ammonium hydroxide; sulfuric acid; ammonium acetate; N-benzyl-N,N,N-triethylammonium chloride; sodium sulfate; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
acetonitrile;
- Guidance literature:
-
C11H15FN2*2ClH;
With
sodium sulfate; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
for 0.166667h;
4-chloro-quinazoline-8-carboxylic acid methyl ester;
In
acetonitrile;
at 45 - 60 ℃;
With
ammonia;
In
methanol;
at 60 ℃;
for 18h;
pressure vessel;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride; pyridine / acetonitrile / -40 - 20 °C
1.2: 18 h / 20 °C
2.1: acetonitrile / 20 °C
3.1: hydrogenchloride / diethyl ether; methanol / 3 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; sodium sulfate / acetonitrile / 0.17 h
4.2: 45 - 60 °C
4.3: 18 h / 60 °C / pressure vessel
With
pyridine; hydrogenchloride; thionyl chloride; sodium sulfate; N-ethyl-N,N-diisopropylamine;
In
methanol; diethyl ether; acetonitrile;
