4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide

Base Information

Chemical Name:4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide
CAS No.:1379545-91-1
Molecular Formula:C₂₀H₂₀FN₅O
Molecular Weight:365.41
Hs Code.:

Synonyms:4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide

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Chemical Property of 4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide

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Technology Process of 4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide

There total 8 articles about 4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39622-79-2
2-aminoisophthalic acid

: 1379545-91-1
4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4 h / 140 °C

2.1: ammonium hydroxide; ammonium acetate / 2 h / 80 °C

2.2: 72 h / 80 °C / pressure bottle

3.1: sulfuric acid / Inert atmosphere; Reflux

4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 90 °C

5.1: N-ethyl-N,N-diisopropylamine; sodium sulfate / acetonitrile / 0.17 h

5.2: 45 - 60 °C

5.3: 18 h / 60 °C / pressure vessel

With ammonium hydroxide; sulfuric acid; ammonium acetate; N-benzyl-N,N,N-triethylammonium chloride; sodium sulfate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In acetonitrile;

Reference yield:

: 903130-01-8
4-chloro-quinazoline-8-carboxylic acid methyl ester

: C₁₁H₁₅FN₂*2ClH

: 1379545-91-1
4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide

Guidance literature:: C₁₁H₁₅FN₂*2ClH; With sodium sulfate; N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.166667h;

4-chloro-quinazoline-8-carboxylic acid methyl ester; In acetonitrile; at 45 - 60 ℃;

With ammonia; In methanol; at 60 ℃; for 18h; pressure vessel;

Reference yield:

: 1035490-58-4
[(S)-1-(3-fluoro-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

: 1379545-91-1
4-[(S)-2-azetidin-1-yl-1-(3-fluorophenyl)-ethylamino]-quinazoline-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride; pyridine / acetonitrile / -40 - 20 °C

1.2: 18 h / 20 °C

2.1: acetonitrile / 20 °C

3.1: hydrogenchloride / diethyl ether; methanol / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; sodium sulfate / acetonitrile / 0.17 h

4.2: 45 - 60 °C

4.3: 18 h / 60 °C / pressure vessel

With pyridine; hydrogenchloride; thionyl chloride; sodium sulfate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; acetonitrile;