N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]nicotinamide

Base Information

Chemical Name:N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]nicotinamide
CAS No.:446052-25-1
Molecular Formula:C₁₇H₁₆F₃N₃O₂
Molecular Weight:351.328
Hs Code.:
Mol file:446052-25-1.mol

Synonyms:N-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]pyridine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]nicotinamide

Chemical Property:

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Technology Process of N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]nicotinamide

There total 3 articles about N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 784-57-6
2-(morpholin-4-yl)-5-(trifluoromethyl)aniline

: 20260-53-1
pyridine-3-carbonyl chloride hydrochloride

: 446052-25-1
N-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]pyridine-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2017.03.078

Reference yield:

: 62054-72-2
4-(2-nitro-4-trifluoromethylphenyl)morpholine

: 446052-25-1
N-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tin(ll) chloride; hydrogenchloride / methanol / 42 h / 0 - 20 °C

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; triethylamine; tin(ll) chloride; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2017.03.078

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 446052-25-1
N-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

2: tin(ll) chloride; hydrogenchloride / methanol / 42 h / 0 - 20 °C

3: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; triethylamine; tin(ll) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2017.03.078