4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide

Base Information

Chemical Name:4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide
CAS No.:1447959-38-7
Molecular Formula:C₂₇H₂₆N₆O₅S
Molecular Weight:546.607
Hs Code.:

Synonyms:4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide

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Chemical Property of 4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide

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Technology Process of 4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide

There total 2 articles about 4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 174227-14-6
p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

: 107-14-2
chloroacetonitrile

: 1447959-38-7
4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide

Guidance literature:: p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide; With sodium carbonate; In N,N-dimethyl-formamide; at 110 - 115 ℃;

chloroacetonitrile; In N,N-dimethyl-formamide; for 8h;
DOI:10.2174/1570178611310050011

Reference yield:

: 150727-06-3
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

: 1447959-38-7
4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / toluene; dimethyl sulfoxide; water / 13 h / 110 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 110 - 115 °C

2.2: 8 h

With sodium carbonate; sodium hydroxide; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.2174/1570178611310050011

Reference yield: 89.0%

: 1447959-38-7
4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide

: 1174918-30-9
4-tert-butyl-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-2,2′-bipyrimidin-4-yl)benzenesulfonamide

Guidance literature:: 4-tert-butyl-N-(6-(cyanomethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl) benzenesulfonamide; With diisobutylaluminium hydride; In toluene; at -70 ℃; for 1.5h;

With hydrogenchloride; sodium hydroxide; In toluene; Reagent/catalyst;
DOI:10.2174/1570178611310050011