N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester

Base Information

Chemical Name:N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester
CAS No.:168540-00-9
Molecular Formula:C₂₅H₃₆N₂O₄
Molecular Weight:428.572
Hs Code.:

Synonyms:N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester

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Chemical Property of N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester

Chemical Property:

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Technology Process of N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester

There total 1 articles about N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7631-86-9,105269-70-3,1317-48-2,13778-37-5,14464-46-1,14808-60-7,14832-85-0,15468-32-3,17679-64-0,87347-84-0,92283-58-4,99439-28-8,15723-40-7
SiO₂

: 168540-00-9
N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester

Guidance literature:

Reference yield:

: 168540-00-9
N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester

: 180311-62-0
(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.29 g / 1 N aq. NaOH / methanol / 4 h / Ambient temperature

2: 2.82 g / HOBT, EDC, Et₃N / dimethylformamide / 24 h / Ambient temperature

3: 2.68 g / HCl (gas) / ethyl acetate / -25 °C

4: 53 percent / NaCNBH₃, KOAc, 3A molecular sieves / methanol / 18 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907

Reference yield:

: 168540-00-9
N-[2(S)-(t-Butoxycarbonylamino)-3(S)-methylpentyl]-N-(1-naphthylmethyl)glycine methyl ester

: (S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 2.29 g / 1 N aq. NaOH / methanol / 4 h / Ambient temperature

2: 2.82 g / HOBT, EDC, Et₃N / dimethylformamide / 24 h / Ambient temperature

3: 2.68 g / HCl (gas) / ethyl acetate / -25 °C

4: 79 percent / KOAc, NaCNBH₃, 3A molecular sieves / methanol / 18 h / Ambient temperature

5: 1 N aq. NaOH / methanol / 0 °C

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907