1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene

Base Information

Chemical Name:1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene
CAS No.:144609-57-4
Molecular Formula:C₂₃H₄₀O₄Si
Molecular Weight:409.646
Hs Code.:

Synonyms:1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene

Suppliers and Price of 1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene

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Technology Process of 1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene

There total 5 articles about 1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 144609-45-0
1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-pent-4-en-1-ol

: 144609-57-4
1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 24 ℃; for 4h;
DOI:10.1021/ja00051a009

Reference yield:

: 2100-17-6
4-pentenal

: 144609-57-4
1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) t-BuLi / 1.) pentane, THF, -78 deg C, 75 min, 2.) from -78 deg C to RT, 1 h

2: 1.) oxalyl chloride, dimethylsulfoxide, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 20 min, 2.) CH₂Cl₂, from -70 deg C to 20 deg C, 2.75 h

3: lithium aluminum deuteride / diethyl ether / 0.42 h / 0 - 20 °C

4: N,N-diisopropylethylamine / CH₂Cl₂ / 4 h / 24 °C

With lithium aluminium deuteride; oxalyl dichloride; tert.-butyl lithium; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ja00051a009

Reference yield:

: 139229-99-5
1-Bromo-4<(tert-butyldimethylsilyl)oxy>-3,5-dimethylbenzene

: 144609-57-4
1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>-1-deuterio-1-<((methoxyethoxy)methyl)oxy>-4-pentene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) t-BuLi / 1.) pentane, THF, -78 deg C, 75 min, 2.) from -78 deg C to RT, 1 h

2: 1.) oxalyl chloride, dimethylsulfoxide, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 20 min, 2.) CH₂Cl₂, from -70 deg C to 20 deg C, 2.75 h

3: lithium aluminum deuteride / diethyl ether / 0.42 h / 0 - 20 °C

4: N,N-diisopropylethylamine / CH₂Cl₂ / 4 h / 24 °C

With lithium aluminium deuteride; oxalyl dichloride; tert.-butyl lithium; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ja00051a009