2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate
• CAS No.: 1374428-29-1
• Molecular Formula: C₁₀H₉F₃O₅S
• Molecular Weight: 298.24
• Mol file: 1374428-29-1.mol

Synonyms:2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate

Chemical Property of 2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate

There total 3 articles about 2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + hydroxy-2-methoxy-6-methyl-4-benzaldehyde (39503-23-6) → 2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate (1374428-29-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ejoc.201101766

Reference yield:

2C9H9O3(1-)*Mg(2+) → 2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate (1374428-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; water; toluene / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; caesium carbonate; In diethyl ether; water; N,N-dimethyl-formamide; toluene;

DOI:10.1002/ejoc.201101766

Reference yield:

2,6-dimethoxy-4-methylbenzaldehyde (6937-96-8) → 2-formyl-3-methoxy-5-methylphenyl trifluoromethanesulfonate (1374428-29-1)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / diethyl ether; toluene / 5 h / Inert atmosphere; Reflux

2: hydrogenchloride / diethyl ether; water; toluene / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; diethyl ether; caesium carbonate; In diethyl ether; water; N,N-dimethyl-formamide; toluene;

DOI:10.1002/ejoc.201101766

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

hydroxy-2-methoxy-6-methyl-4-benzaldehyde

2,6-dimethoxy-4-methylbenzaldehyde

Downstream raw materials:

2-(2,2-dibromovinyl)-1-methoxy-5-methyl-3-vinylbenzene

methyl 3-(2-methoxy-4-methyl-6-vinylphenyl)propiolate

methyl 3-(2-(2-hydroxyethyl)-6-methoxy-4-methylphenyl)propiolate

methyl 3-(2-methoxy-4-methyl-6-(2-oxoethyl)phenyl)propiolate