N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

Base Information

Chemical Name:N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine
CAS No.:1610625-66-5
Molecular Formula:C₄₇H₅₅N₇O₁₃S₄
Molecular Weight:1054.26
Hs Code.:

N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

Synonyms:N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

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Chemical Property of N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

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Technology Process of N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

There total 13 articles about N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.8%

: 1610625-65-4
N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-(methoxycarbonyl)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

: 96-53-7
2-mercaptothiazoline

: 1610625-66-5
N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

Guidance literature:: N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-(methoxycarbonyl)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine; With sodium hydroxide; In tetrahydrofuran; water; for 23h;

2-mercaptothiazoline; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

Reference yield:

: 24207-22-5
2-bromo-3-methoxy-6-methyl-pyridine

: 1610625-66-5
N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium permanganate / water

2.1: triethylamine; dmap / dichloromethane

3.1: aluminum (III) chloride / dichloromethane

4.1: potassium carbonate / acetonitrile / 6 h / Reflux

5.1: sodium hydroxide / water; tetrahydrofuran / 5 h

6.1: trifluoroacetic acid; dihydrogen peroxide / water / 3 h / 80 °C / Inert atmosphere

7.1: potassium hydroxide / water / 36 h / 80 °C / Inert atmosphere

8.1: chloro-trimethyl-silane / 44 h / Inert atmosphere

8.2: 6 h / Reflux

9.1: sodium hydroxide / water; tetrahydrofuran

10.1: 1-hydroxy-pyrrolidine-2,5-dione; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 6 h / Inert atmosphere

10.2: 22 h / Inert atmosphere

11.1: sodium hydroxide / water; tetrahydrofuran / 23 h

11.2: 18 h

With dmap; aluminum (III) chloride; potassium permanganate; 1-hydroxy-pyrrolidine-2,5-dione; chloro-trimethyl-silane; dihydrogen peroxide; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 170235-18-4
methyl 2-bromo-3-methoxy-6-pyridinecarboxylic acid

: 1610625-66-5
N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: aluminum (III) chloride / dichloromethane

2.1: potassium carbonate / acetonitrile / 6 h / Reflux

3.1: sodium hydroxide / water; tetrahydrofuran / 5 h

4.1: trifluoroacetic acid; dihydrogen peroxide / water / 3 h / 80 °C / Inert atmosphere

5.1: potassium hydroxide / water / 36 h / 80 °C / Inert atmosphere

6.1: chloro-trimethyl-silane / 44 h / Inert atmosphere

6.2: 6 h / Reflux

7.1: sodium hydroxide / water; tetrahydrofuran

8.1: 1-hydroxy-pyrrolidine-2,5-dione; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 6 h / Inert atmosphere

8.2: 22 h / Inert atmosphere

9.1: sodium hydroxide / water; tetrahydrofuran / 23 h

9.2: 18 h

With aluminum (III) chloride; 1-hydroxy-pyrrolidine-2,5-dione; chloro-trimethyl-silane; dihydrogen peroxide; potassium carbonate; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;