2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione
• CAS No.: 1269797-22-9
• Molecular Formula: C₂₄H₂₈FN₃O₃
• Molecular Weight: 425.503

Synonyms:2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione

Chemical Property of 2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione

Chemical Property:

Purity/Quality:

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Technology Process of 2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione

There total 2 articles about 2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-fluoroethyl bromide (762-49-2) + 2-{4-[4-(2-hydroxyphenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione (927187-08-4) → 2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione (1269797-22-9)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1021/jm101323b

Reference yield:

2-hydroxyphenylpiperazine (1011-17-2) + 2-(4-bromobutyl)isoindoline-1,3-dione (5394-18-3) → 2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione (1269797-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 15 h / 20 °C

2: potassium carbonate / acetone / Reflux

With potassium carbonate; triethylamine; In dichloromethane; acetone;

DOI:10.1021/jm101323b

Reference yield: 90.0%

2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione (1269797-22-9) → 4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butan-1-amine (1138217-76-1)

Guidance literature:

With hydrazine; In ethanol; for 5h; Reflux;

DOI:10.1021/jm101323b

upstream raw materials:

2-hydroxyphenylpiperazine

2-(4-bromobutyl)isoindoline-1,3-dione

2-fluoroethyl bromide

2-{4-[4-(2-hydroxyphenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butan-1-amine

4-(dimethylamino)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

4-(2-fluoroethyl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

4-(2-fluoroethoxy)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

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