(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Base Information

Chemical Name:(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide
CAS No.:1252637-35-6
Molecular Formula:C₂₅H₂₃F₆N₅O₄S
Molecular Weight:603.545
Hs Code.:

(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Synonyms:(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Suppliers and Price of (2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Petesicatib 98.80%
100mg
$ 3950.00

ChemScene
Petesicatib 98.80%
50mg
$ 2950.00

ChemScene
Petesicatib 98.80%
10mg
$ 850.00

ChemScene
Petesicatib 98.80%
5mg
$ 550.00

Total 5 raw suppliers

Chemical Property of (2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Petesicatib 98.80% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

There total 16 articles about (2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.9%

: 1434818-70-8
(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

: 1252637-35-6
(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: With disodium hydrogenphosphate; monoperoxyphthalic acid magnesium salt hexahydrate; In acetonitrile; at 5 - 50 ℃; for 21h;

Reference yield: 17.0%

: 1252637-36-7
(2S,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1252637-35-6
(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: With sodium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; In water; N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 277756-46-4
1-(trifluoromethyl)cyclopropanecarboxylic acid

: 1252637-35-6
(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / toluene; N,N-dimethyl-formamide / 4.92 h / 2 - 20 °C

2.1: triethylamine / toluene; N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 0 - 20 °C

3.1: sodium 2-ethylhexanoic acid / water / 20 h / 53 °C

4.1: triethylamine; dmap / tetrahydrofuran / 20.25 h / 2 - 20 °C

5.1: sodium t-butanolate / tetrahydrofuran; N,N-dimethyl acetamide / 4.5 h / 20 °C

5.2: 42 h / 20 °C

6.1: Monoperoxyphthalic acid, magnesium salt / acetonitrile / 21 h / 50 °C

With dmap; oxalyl dichloride; Monoperoxyphthalic acid, magnesium salt; triethylamine; sodium t-butanolate; sodium 2-ethylhexanoic acid; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene; acetonitrile;