(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Base Information

Chemical Name:(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide
CAS No.:1434818-70-8
Molecular Formula:C₂₅H₂₃F₆N₅O₂S
Molecular Weight:571.546
Hs Code.:

(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Synonyms:(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

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Chemical Property of (2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

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Technology Process of (2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

There total 14 articles about (2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

: 1434817-93-2
4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylbenzenethiol

: 1434818-13-9
benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

: 1434818-70-8
(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 20 - 28 ℃; for 18.33h;

Reference yield:

: 1434817-59-0
3-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]propionamide

: 1434818-13-9
benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

: 1434818-70-8
(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: 3-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]propionamide; With sodium t-butanolate; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 4.5h;

benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 42h;

Reference yield:

: 277756-46-4
1-(trifluoromethyl)cyclopropanecarboxylic acid

: 1434818-70-8
(2S,4R)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylphenylsulfanyl]-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / toluene; N,N-dimethyl-formamide / 4.92 h / 2 - 20 °C

2.1: triethylamine / toluene; N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 0 - 20 °C

3.1: sodium 2-ethylhexanoic acid / water / 20 h / 53 °C

4.1: triethylamine; dmap / tetrahydrofuran / 20.25 h / 2 - 20 °C

5.1: sodium t-butanolate / tetrahydrofuran; N,N-dimethyl acetamide / 4.5 h / 20 °C

5.2: 42 h / 20 °C

With dmap; oxalyl dichloride; triethylamine; sodium t-butanolate; sodium 2-ethylhexanoic acid; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene;