N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester
CAS No.:916850-86-7
Molecular Formula:C₂₄H₃₆N₂O₆
Molecular Weight:448.56
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester

Suppliers and Price of N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester

There total 4 articles about N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 916850-84-5
N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valine

: 2133-40-6
L-proline methyl ester monohydrochloride

: 916850-86-7
N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1016/j.tetlet.2006.09.046

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 916850-86-7
N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / NaBH₃CN / methanol

2: 27 percent / i-Pr₂NEt / dioxane; H₂O

3: 87 percent / EDCI; HOBT; Et₃N / CH₂Cl₂

With sodium cyanoborohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/j.tetlet.2006.09.046

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 916850-86-7
N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-valinyl-L-proline methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / NaBH₃CN / methanol

2: 27 percent / i-Pr₂NEt / dioxane; H₂O

3: 87 percent / EDCI; HOBT; Et₃N / CH₂Cl₂

With sodium cyanoborohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/j.tetlet.2006.09.046