L-Ornithine, 2-methyl-

Base Information

• Chemical Name: L-Ornithine, 2-methyl-
• CAS No.: 48047-95-6
• Molecular Formula: C₆H₁₄N₂O₂
• Molecular Weight: 146.189
• DSSTox Substance ID: DTXSID701315156
• Nikkaji Number: J396.559G
• ChEMBL ID: CHEMBL3303506
• Mol file: 48047-95-6.mol

Synonyms:L-Ornithine, 2-methyl-;48047-95-6;2-methyl-l-ornithine;L-Ornithine, 2-methyl- (9CI);alpha-methyl-l-ornithine;(S)-2,5-Diamino-2-methylpentanoic acid;2-Methylornithine;(2S)-2,5-diamino-2-methylpentanoic acid;SCHEMBL162369;CHEMBL3303506;DTXSID701315156;(S)-2,5-Diamino-2-methylpentanoicacid

Chemical Property of L-Ornithine, 2-methyl-

Chemical Property:

• Vapor Pressure: 0.000211mmHg at 25°C
• Boiling Point: 303.7°Cat760mmHg
• Flash Point: 137.5°C
• Density: 1.127g/cm³
• XLogP3: -3.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 146.105527694
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CCCN)(C(=O)O)N
• Isomeric SMILES: C[C@](CCCN)(C(=O)O)N

Technology Process of L-Ornithine, 2-methyl-

There total 15 articles about L-Ornithine, 2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S)-4-Cyano-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid (151074-89-4) → α-methyl-L-ornithine (48047-95-6)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; for 0.166667h;

DOI:10.1021/jo00074a016

Reference yield: 61.0%

C7H10N2O2 → (R)-2-methylornithin (59574-27-5,48047-95-6)

Guidance literature:

C₇H₁₀N₂O₂; With hydrogenchloride; In methanol; water; for 24h; Inert atmosphere; Reflux;

With ammonium hydroxide; In water; at 0 ℃; Inert atmosphere;

DOI:10.1021/jacs.7b08496

Reference yield:

N-(3-iodopropyl)phthalimide (5457-29-4) + methyl 2-(benzylideneamino)propanoate (40216-71-5) → α-Methylornithin (48047-94-5,48047-95-6)

Guidance literature:

Multistep reaction; (i) LDA, THF, (ii) /BRN= 157555/, (iii) aq. HCl;

DOI:10.1021/jm00199a009

upstream raw materials:

3-amino-3-methyl-piperidin-2-one

(R)-2-Amino-5-guanidino-2-methyl-pentanoic acid

(S)-3-allyl-1-benzoyl-3-methylpiperidin-2-one

C₉H₁₅NO