(S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate
CAS No.:1442445-69-3
Molecular Formula:C₂₄H₂₉Cl₂N₅O₃
Molecular Weight:506.432
Hs Code.:

Synonyms:(S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

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Chemical Property of (S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

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Technology Process of (S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

There total 5 articles about (S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1442445-69-3
(S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C / Resolution of racemate

1.2: 1 h / 20 °C / Resolution of racemate

2.1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 125 °C

4.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

5.1: isopentyl nitrite / dichloromethane / 18 h / 20 °C

With (S)-Mandelic acid; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1442445-68-2
(S)-tert-butyl 4-(4-amino-3-((R)-1-(2,4-dichlorophenyl)ethylamino)phenyl)-2-(hydroxymethyl)piperazine-1-carboxylate

: 1442445-69-3
(S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: With isopentyl nitrite; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 133773-29-2
(R)-2,4-dichloro-α-methylbenzylamine

: 1442445-69-3
(S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

2: potassium carbonate / dimethyl sulfoxide / 2 h / 125 °C

3: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

4: isopentyl nitrite / dichloromethane / 18 h / 20 °C

With iron; potassium carbonate; ammonium chloride; isopentyl nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide;