((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol

Base Information

Chemical Name:((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol
CAS No.:1442445-70-6
Molecular Formula:C₁₉H₂₁Cl₂N₅O
Molecular Weight:406.315
Hs Code.:

Synonyms:((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol

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Chemical Property of ((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol

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Technology Process of ((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol

There total 6 articles about ((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1442445-69-3
(S)-tert-butyl 4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-2-(hydroxymethyl)piperazine-1-carboxylate

: 1442445-70-6
((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1442445-70-6
((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C / Resolution of racemate

1.2: 1 h / 20 °C / Resolution of racemate

2.1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 125 °C

4.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

5.1: isopentyl nitrite / dichloromethane / 18 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With (S)-Mandelic acid; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isopentyl nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 133773-29-2
(R)-2,4-dichloro-α-methylbenzylamine

: 1442445-70-6
((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)piperazin-2-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 125 °C

3: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

4: isopentyl nitrite / dichloromethane / 18 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isopentyl nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide;