Technology Process of 5-(3,4,5-trimethoxyphenyl)-1-(4-methoxyphenyl)-1H-tetrazole
There total 3 articles about 5-(3,4,5-trimethoxyphenyl)-1-(4-methoxyphenyl)-1H-tetrazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
ethanol; water; toluene;
at 120 ℃;
for 18h;
Inert atmosphere;
DOI:10.1021/jm2013979
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux; Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 18 h / 120 °C / Inert atmosphere
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); sodium carbonate; dibenzoyl peroxide;
In
tetrachloromethane; ethanol; water; toluene;
2: Suzuki coupling;
DOI:10.1021/jm2013979
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium azide / acetic acid / 4 h / Reflux; Inert atmosphere
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux; Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 18 h / 120 °C / Inert atmosphere
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); sodium azide; sodium carbonate; dibenzoyl peroxide;
In
tetrachloromethane; ethanol; water; acetic acid; toluene;
3: Suzuki coupling;
DOI:10.1021/jm2013979