ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate

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Chemical Name:ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate
CAS No.:1393126-59-4
Molecular Formula:C₂₅H₂₇F₃N₄O₄
Molecular Weight:504.509
Hs Code.:

Synonyms:ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate

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Chemical Property of ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate

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Technology Process of ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate

There total 4 articles about ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1393126-58-3
(+/-)-5-bromo-2-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)pyridine

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1393126-59-4
ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In acetonitrile; at 170 ℃; for 0.0333333h; Microwave irradiation;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1393126-59-4
ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / toluene / 0.5 h / -78 - -70 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 - 50 °C

3.1: caesium carbonate / 4R-4-hydroxyproline; copper(l) iodide / dimethyl sulfoxide / 18 h / 85 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / acetonitrile / 0.03 h / 170 °C / Microwave irradiation

With n-butyllithium; di-isopropyl azodicarboxylate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; copper(l) iodide; palladium diacetate; 4R-4-hydroxyproline; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran; dimethyl sulfoxide; toluene; acetonitrile; 2.1: Mitsunobu reaction;

Reference yield:

: 1393125-47-7
(+/-)-5-bromo-2-(1-(4-iodophenoxy)butyl)pyridine

: 1393126-59-4
ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 4R-4-hydroxyproline; copper(l) iodide / dimethyl sulfoxide / 18 h / 85 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / acetonitrile / 0.03 h / 170 °C / Microwave irradiation

With caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(l) iodide; palladium diacetate; 4R-4-hydroxyproline; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In dimethyl sulfoxide; acetonitrile;