3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid

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Chemical Name:3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid
CAS No.:1393122-60-5
Molecular Formula:C₂₃H₂₃F₃N₄O₄
Molecular Weight:476.455
Hs Code.:

Synonyms:3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid

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Chemical Property of 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid

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Technology Process of 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid

There total 5 articles about 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1393126-59-4
ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate

: 1393122-60-5
3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid

Guidance literature:: ethyl 3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoate; With methanol; sodium hydroxide; at 20 ℃; for 6h;

With hydrogenchloride; In methanol; water; pH=4;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1393122-60-5
3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / toluene / 0.5 h / -78 - -70 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 - 50 °C

3.1: caesium carbonate / 4R-4-hydroxyproline; copper(l) iodide / dimethyl sulfoxide / 18 h / 85 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / acetonitrile / 0.03 h / 170 °C / Microwave irradiation

5.1: sodium hydroxide; methanol / 6 h / 20 °C

5.2: pH 4

With methanol; n-butyllithium; di-isopropyl azodicarboxylate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium hydroxide; copper(l) iodide; palladium diacetate; 4R-4-hydroxyproline; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran; dimethyl sulfoxide; toluene; acetonitrile; 2.1: Mitsunobu reaction;

Reference yield:

: 1393125-47-7
(+/-)-5-bromo-2-(1-(4-iodophenoxy)butyl)pyridine

: 1393122-60-5
3-(6-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)nicotinamido)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 4R-4-hydroxyproline; copper(l) iodide / dimethyl sulfoxide / 18 h / 85 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / acetonitrile / 0.03 h / 170 °C / Microwave irradiation

3.1: sodium hydroxide; methanol / 6 h / 20 °C

3.2: pH 4

With methanol; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; copper(l) iodide; palladium diacetate; 4R-4-hydroxyproline; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In dimethyl sulfoxide; acetonitrile;