2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile

Base Information

Chemical Name:2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile
CAS No.:1443776-44-0
Molecular Formula:C₂₇H₂₄N₆O₂
Molecular Weight:464.527
Hs Code.:

Synonyms:2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile

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Chemical Property of 2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile

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Technology Process of 2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile

There total 7 articles about 2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1073354-05-8
2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile

: 1431542-31-2
(R)-4-[3-(6-bromo-quinazolin-4-yl)-benzoyl]-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1443776-44-0
2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 140 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1431542-29-8
3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester

: 1443776-44-0
2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 38267-96-8
6-bromo-4-chloroquinozoline

: 1443776-44-0
2-methoxy-5-{4-[3-((R)-3-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin yl}-nicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.25 h / 100 °C / Inert atmosphere; Microwave irradiation

2.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C

3.2: 2 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium acetate; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling;