N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

Base Information

Chemical Name:N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide
CAS No.:156100-64-0
Molecular Formula:C₃₈H₃₆N₆O₅
Molecular Weight:656.741
Hs Code.:

Synonyms:N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

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Chemical Property of N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

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Technology Process of N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

There total 9 articles about N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 170236-43-8
N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

: 156100-64-0
N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

Guidance literature:: With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; In ethanol; water; for 6h;
DOI:10.1021/jo8018889

Reference yield: 74.0%

: C₄₆H₄₂N₆O₇

: 156100-64-0
N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; at 25 ℃; for 18h; under 2585.81 Torr;

Reference yield:

: C₂₄H₃₄N₆O₄Si

: 156100-64-0
N-[9-[(2R,4S,5S)-4-amino-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 12 h / 25 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C

3: pyridine / 2 h / 25 °C

4: hydrogen; palladium 10% on activated carbon / 18 h / 25 °C / 2585.81 Torr

With pyridine; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; In tetrahydrofuran;