N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

Base Information

Chemical Name:N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide
CAS No.:170236-43-8
Molecular Formula:C₃₈H₃₄N₈O₅
Molecular Weight:682.739
Hs Code.:

Synonyms:N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

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Technology Process of N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

There total 5 articles about N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 869354-89-2
3'-azido-N₆-benzoyl-2',3'-dideoxyadenosine

: 170236-43-8
N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

Guidance literature:: With pyridine; for 4h;
DOI:10.1021/jo8018889

Reference yield: 63.0%

: 934980-56-0
[(2R,3R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-3-yl] methanesulfonate

: 170236-43-8
N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

Guidance literature:: With sodium azide; 15-crown-5; In N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 139260-81-4
N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]purin-6-yl]benzamide

: 170236-43-8
N-[9-[(2R,4S,5S)-4-azido-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]tetrahydrofuran-2-yl]-9H-purin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 16 h / 20 °C / Inert atmosphere

2: 15-crown-5; sodium azide / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

With pyridine; sodium azide; 15-crown-5; In N,N-dimethyl-formamide;