Ethyl 2-(acetylamino)-3-(4-fluorophenyl)-2-propenoate

Base Information

Chemical Name:Ethyl 2-(acetylamino)-3-(4-fluorophenyl)-2-propenoate
CAS No.:401-12-7
Molecular Formula:C₁₃H₁₄FNO₃
Molecular Weight:251.257
Hs Code.:
DSSTox Substance ID:DTXSID901215627

Synonyms:DTXSID901215627;Ethyl 2-(acetylamino)-3-(4-fluorophenyl)-2-propenoate;401-12-7

Suppliers and Price of Ethyl 2-(acetylamino)-3-(4-fluorophenyl)-2-propenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-(acetylamino)-3-(4-fluorophenyl)-2-propenoate

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:251.09577147
Heavy Atom Count:18
Complexity:333

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(=CC1=CC=C(C=C1)F)NC(=O)C

Technology Process of Ethyl 2-(acetylamino)-3-(4-fluorophenyl)-2-propenoate

There total 4 articles about Ethyl 2-(acetylamino)-3-(4-fluorophenyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.2%

: 64-17-5
ethanol

: 125772-83-0
(Z)-4-(4-fluorobenzylidene)-2-methyloxazol-5(4H)-one

: 401-12-7
ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate

Guidance literature:: With triethylamine; at 100 ℃; for 3h;
DOI:10.1021/acs.orglett.6b01592

Reference yield:

: 166116-63-8
4-(4-fluoro-benzylidene)-2-methyl-4H-oxazol-5-one

: 401-12-7
ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate

Guidance literature:: With sodium ethanolate;
DOI:10.1021/ja01160a113

Reference yield:

: 360-23-6
N-benzenesulfonyl-N'-(4-fluoro-benzoyl)-hydrazine

: 401-12-7
ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂CO₃; ethylene glycol

2: sodium acetate; acetic acid anhydride

3: ethanolic sodium ethylate

With sodium ethanolate; sodium acetate; acetic anhydride; sodium carbonate; ethylene glycol;
DOI:10.1021/ja01160a113