p-Fluoro-a-acetamidocinnamic Acid

Base Information

• Chemical Name: p-Fluoro-a-acetamidocinnamic Acid
• CAS No.: 111649-72-0
• Molecular Formula: C₁₁H₁₀FNO₃
• Molecular Weight: 223.204
• Mol file: 111649-72-0.mol

Synonyms:p-Fluoro-α-acetamidocinnamic Acid

Chemical Property of p-Fluoro-a-acetamidocinnamic Acid

Chemical Property:

• Vapor Pressure: 5.61E-09mmHg at 25°C
• Melting Point: 222-223°C
• Refractive Index: 1.586
• Boiling Point: 452.5°C at 760 mmHg
• Flash Point: 227.5°C
• PSA: 66.40000
• Density: 1.328g/cm³
• LogP: 1.77820
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

p-Fluoro-α-acetamidocinnamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: p-Fluoro-α-acetamidocinnamic Acid (cas# 111649-72-0) is a compound useful in organic synthesis.

Technology Process of p-Fluoro-a-acetamidocinnamic Acid

There total 4 articles about p-Fluoro-a-acetamidocinnamic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-fluoro-benzylidene)-2-methyl-4H-oxazol-5-one (166116-63-8) → α-acetylamino-4-fluoro-cinnamic acid (111649-72-0)

Guidance literature:

With water; In acetone; for 4h; Heating;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → α-acetylamino-4-fluoro-cinnamic acid (111649-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOAc / acetic anhydride / 1 h / Heating

2: H₂O / acetone / 4 h / Heating

With water; sodium acetate; In acetic anhydride; acetone;

Reference yield:

ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate (401-12-7) → α-acetylamino-4-fluoro-cinnamic acid (111649-72-0)

Guidance literature:

With sodium hydroxide; Hydrolysis;

DOI:10.1021/ja01160a113

upstream raw materials:

ethyl (Z)-2-acetamido-3-(4-fluorophenyl)acrylate

4-(4-fluoro-benzylidene)-2-methyl-4H-oxazol-5-one

4-fluorobenzaldehyde

N-benzenesulfonyl-N'-(4-fluoro-benzoyl)-hydrazine

Downstream raw materials:

sodium 3-(4-fluorophenyl)-2-oxopropionate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 111649-72-0 p-Fluoro-a-acetamidocinnamic Acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send