3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine

Base Information

• Chemical Name: 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine
• CAS No.: 96843-03-7
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.371
• Mol file: 96843-03-7.mol

Synonyms:3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine

Chemical Property of 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine

There total 7 articles about 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylpropylamine (99484-36-3) → 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine (96843-03-7)

Guidance literature:

With zinc; In acetic acid; at 20 ℃; for 1h;

DOI:10.1002/jps.2600740112

Reference yield:

α-(2-methoxyphenyl)benzyl chloride (68240-60-8) → 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine (96843-03-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 35 percent / acetonitrile / 5 h / Heating

2: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -30 deg C up to 0 deg C, 2.) reflux, 1.5 h

3: 48percent HBr / 40 h / Heating

4: lithium tetrahydridoaluminate / diethyl ether / 2 h / 20 °C

5: Et₃N / CH₂Cl₂ / 3 h / 5 °C

6: potassium carbonate (anhyd.) / CH₂Cl₂ / 20 °C

7: activated zinc / acetic acid / 1 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; hydrogen bromide; potassium carbonate; triethylamine; diisopropylamine; zinc; In diethyl ether; dichloromethane; acetic acid; acetonitrile;

DOI:10.1002/jps.2600740112

Reference yield:

α-(2-methoxyphenyl)benzeneacetonitrile (51355-29-4) → 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine (96843-03-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -30 deg C up to 0 deg C, 2.) reflux, 1.5 h

2: 48percent HBr / 40 h / Heating

3: lithium tetrahydridoaluminate / diethyl ether / 2 h / 20 °C

4: Et₃N / CH₂Cl₂ / 3 h / 5 °C

5: potassium carbonate (anhyd.) / CH₂Cl₂ / 20 °C

6: activated zinc / acetic acid / 1 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; hydrogen bromide; potassium carbonate; triethylamine; diisopropylamine; zinc; In diethyl ether; dichloromethane; acetic acid;

DOI:10.1002/jps.2600740112

upstream raw materials:

3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylpropylamine

α-(2-methoxyphenyl)benzyl chloride

α-(2-methoxyphenyl)benzeneacetonitrile

3-(2-oxo-3-phenyl-3-dihydrobenzofuranyl)-N,N-dimethylpropylamine