51355-29-4

Upstream product

• 5798-79-8 bromo-phenyl-acetonitrile 
• 100-66-3 methoxybenzene 
• 68240-60-8 α-(2-methoxyphenyl)benzyl chloride 
• 506-64-9 silver(I) cyanide 

Downstream Products

• 96842-80-7 5-dimethylamino-2-(2-hydroxyphenyl)-2-phenylpentanol 
• 99484-32-9 4-dimethylamino-2-(2-hydroxyphenyl)-2-phenylbutanol 
• 96842-89-6 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N,N-dimethylpropylamine 
• 96843-03-7 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine 
• 96842-82-9 2-(3-phenyl-3-dihydrobenzofuranyl)-N,N-dimethylaminoethanamine 
• 96843-02-6 2,3-dihydro-N-methyl-3-phenyl-3-benzofuranethanamine 
• 99484-36-3 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylpropylamine 
• 99484-33-0 2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine 
• 99484-55-6 3-(2-oxo-3-phenyl-3-dihydrobenzofuranyl)-N,N-dimethylpropylamine 
• 96842-99-8 3-(2-dimethylamino-ethyl)-3-phenyl-3H-benzofuran-2-one 
• 96842-65-8 4-dimethylamino-2-(2-methoxyphenyl)-2-phenylbutanenitrile 
• 99484-46-5 5-Dimethylamino-2-(2-methoxy-phenyl)-2-phenyl-pentanenitrile 

Relevant academic research and scientific papers

Phenyl-substituted normethadones: Synthesis and pharmacology

Phenyl-substituted normethadone derivatives were synthesized and their affinity (IC50) for opioid receptors was determined by displacement of the specific binding sites of [3H]sufentanyl on rat brain preparations. Substitution resulted in a decrease of affinity in-vitro. These results suggest that normethadone-like compounds may interact with the P subsite of the μ-opioid receptor and that the P subsite has a well-defined cavity shape of stringent dimensions.

Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines

There are described compounds of the formula STR1 where n is 2 or 3, X and Y are each independently hydrogen, loweralkyl, or halogen, and R1 and R2 are each independently hydrogen, loweralkyl, cyano, beta,beta,beta-trichloroethyoxyca

Efforts toward combined analgesic/antidepressants: Synthesis and evaluation of (3-aryl-2,3-dihydrobenzofuran-3-yl)alkanamines

Several (3-aryl-2,3-dihydrobenzofuran-3-yl)alkanamines, designed as potential antidepressant agents with analgesic properties, were synthesized and pharmacologically evaluated. While two compounds displayed potent antitetrabenazine activity, concomitant antinociceptive activity in the phenylquinone writhing assay was not observed.