(-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

Base Information

Chemical Name:(-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide
CAS No.:194785-64-3
Molecular Formula:C₃₈H₄₄N₂O₅
Molecular Weight:608.778
Hs Code.:

Synonyms:(-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

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Chemical Property of (-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

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Technology Process of (-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

There total 9 articles about (-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-brorno-N,N-dimethylacetamide

: 5468-77-9
2-bromo-N,N-dimethylethanamide

: 109-89-7
diethylamine

: 194785-70-1
(-)-(1R)-1-[4-benzyloxy-3-(2-benzyloxyethyl)phenyl]-2-((2S)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylamino)ethanol

: 194785-64-3
(-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

Guidance literature:: With sodium hydroxide; In dichloromethane;

Reference yield:

: 95-92-1
oxalic acid diethyl ester

: 194785-65-4
benzyl 2-(2-benzyloxyethyl)-4-bromophenyl ether

: 194785-66-5
ethyl 2-[4-benzyloxy-3-(2-benzyloxyethyl)phenyl]-2-hydroxyacetate

: 194785-64-3
(-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

Guidance literature:: With n-butyllithium; sodium borohydrid; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; ethanol; hexane; water;

Reference yield:

: 158223-16-6
(2S)-7-methoxy-1,2,3,4-tetrahydro-2-naphthylamine hydrochloride

: 194785-64-3
(-)-2-[(2S)-2-[[(2R)-2-[4-Benzyloxy-3-(2-benzyloxyethyl)-phenyl]-2-hydroxyethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaOH

1.2: 99 percent / 48 percent aq. HBr / 4 h / Heating

2.1: BH₃*Me₂S

With sodium hydroxide; dimethylsulfide borane complex;
DOI:10.1248/cpb.49.1018