methyl 4-(1-(2-(7-fluoro-1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

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Chemical Name:methyl 4-(1-(2-(7-fluoro-1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate
CAS No.:1569975-83-2
Molecular Formula:C₂₈H₂₂FN₃O₅
Molecular Weight:499.498
Hs Code.:

Synonyms:methyl 4-(1-(2-(7-fluoro-1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-(1-(2-(7-fluoro-1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

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Technology Process of methyl 4-(1-(2-(7-fluoro-1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

There total 2 articles about methyl 4-(1-(2-(7-fluoro-1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 159730-09-3
2-(7-fluoro-1H-indol-3-yl)ethanamine hydrochloride

: 778531-36-5
(Z)-ethyl 2-hydroxy-4-oxo-4-(pyridin-3-yl)but-2-enoate

: 1571-08-0
methyl 4-formylbenzoate

: 1569975-83-2
methyl 4-(1-(2-(7-fluoro-1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

Guidance literature:: With pyridinium p-toluenesulfonate; In 1,4-dioxane; at 20 ℃; for 12h;
DOI:10.1021/jm401695d

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 1569975-83-2
methyl 4-(1-(2-(7-fluoro-1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol / 4.33 h / 0 - 20 °C

2: pyridinium p-toluenesulfonate / 1,4-dioxane / 12 h / 20 °C

With sodium ethanolate; pyridinium p-toluenesulfonate; In 1,4-dioxane; ethanol;
DOI:10.1021/jm401695d