2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane
• CAS No.: 1346621-06-4
• Molecular Formula: C₁₃H₁₈N₄O
• Molecular Weight: 246.312
• Mol file: 1346621-06-4.mol

Synonyms:2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane

Chemical Property of 2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane

There total 8 articles about 2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

hexamethylenetetramine (100-97-0) + 4-hydroxy-6-(4-methoxyphenyl)-5-[(4-methylphenyl)sulfonyl]-4-(trifluoromethyl)-tetrahydropyrimidin-2(1H)-one → 2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane (1346621-06-4) + 4-hydroxy-5-[(4-methylphenyl)sulfonyl]-4-(trifluoromethyl)-tetrahydropyrimidin-2(1H)-one

Guidance literature:

In toluene; for 5h; Reflux;

DOI:10.1016/j.tetlet.2011.09.143

Reference yield: 66.0%

hexamethylenetetramine (100-97-0) + 4-hydroxy-6-(4-methoxyphenyl)-5-[(4-methylphenyl)sulfonyl]-4-(1,1,2,2-tetrafluoroethyl)-tetrahydropyrimidin-2(1H)-one → 2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane (1346621-06-4) + 4-hydroxy-5-[(4-methylphenyl)sulfonyl]-4-(1,1,2,2-tetrafluoroethyl)-tetrahydro-pyrimidin-2(1H)-one

Guidance literature:

In toluene; for 5h; Reflux;

DOI:10.1016/j.tetlet.2011.09.143

Reference yield: 64.0%

hexamethylenetetramine (100-97-0) + N,N-diethyl-4-hydroxy-2-oxo-6-(4-methoxyphenyl)-4-(trifluoromethyl)-hexahydro-pyrimidine-5-sulfonamide → 2-(4-methoxyphenyl)-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane (1346621-06-4) + N,N-diethyl-4-hydroxy-2-oxo-4-(trifluoromethyl)-hexahydropyrimidine-5-sulfonamide

Guidance literature:

In toluene; for 5h; Reflux;

DOI:10.1016/j.tetlet.2011.09.143

upstream raw materials:

N-(2,2,2-trifluoro-1-hydroxy-1-{[(4-methylphenyl)sulfonyl]methyl}ethyl)urea

4-methoxy-benzaldehyde

hexamethylenetetramine