methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate

Base Information

Chemical Name:methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate
CAS No.:185199-60-4
Molecular Formula:C₂₄H₃₅NO₈
Molecular Weight:465.544
Hs Code.:

Synonyms:methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate

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Technology Process of methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate

There total 5 articles about methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 185199-60-4
methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate

Guidance literature:

Reference yield:

: 165529-97-5
2-[1-[5-tert-Butoxycarbonyl-2-(tert-butoxycarbonylamino-methyl)-phenyl]-meth-(E)-ylidene]-succinic acid dimethyl ester

: 185199-60-4
methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate

Guidance literature:: With hydrogen; palladium dihydroxide; palladium on activated charcoal; In methanol; ethyl acetate; under 2585.7 Torr; Yield given;
DOI:10.1016/0960-894X(96)00432-5

Reference yield:

: 160952-57-8
3-bromo-4-methylbenzoic acid tert-butyl ester

: 185199-60-4
methyl (R,S)-3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[(t-butoxycarbonyl)amino]methyl]phenyl]butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: NBS, (PhCO)2O₂ / CCl₄ / Heating

2: dimethylformamide / 60 °C

3: 95 percent / 1 N NaOH / methanol

4: Pd(OAc)2, P(o-tol)3, (i-Pr)2NEt / various solvent(s) / Heating

5: H₂ / 10percent Pd/C, Pd(OH)2/C / ethyl acetate; methanol / 2585.7 Torr

With palladium diacetate; sodium hydroxide; N-Bromosuccinimide; hydrogen; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; dibenzoyl peroxide; palladium dihydroxide; palladium on activated charcoal; In methanol; tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00432-5