methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester

Base Information

Chemical Name:methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester
CAS No.:791814-79-4
Molecular Formula:C₃₂H₃₉NO₇S
Molecular Weight:581.73
Hs Code.:

methanesulfonic acid 2-[2-(6-{3-[<i>tert</i>-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester

Synonyms:methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester

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Chemical Property of methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester

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Technology Process of methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester

There total 10 articles about methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 791814-78-3
(3-{6-[2-(2-hydroxy-ethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-propyl)-(1-phenyl-ethyl)-carbamic acid tert-butyl ester

: 791814-79-4
methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo049157q

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 791814-79-4
methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / Br₂; FeCl₃; AcOH

2: 77 percent / Pd(OAc)2; Ph₃P; aq. NaHCO₃ / dioxane / 12 h / Heating

3: 71 percent / tetrahexylammonium iodide; aq. NaOH / CH₂Cl₂

4: 88 percent / H₂ / Pd/C / methanol / 760 Torr

5: BH₃*SMe₂ / tetrahydrofuran

6: 0.79 g / CH₂Cl₂

7: 99 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With palladium diacetate; sodium hydroxide; dimethylsulfide borane complex; hydrogen; bromine; iron(III) chloride; sodium hydrogencarbonate; tetrahexylammonium iodide; acetic acid; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 2: Suzuki coupling;
DOI:10.1021/jo049157q

Reference yield:

: 1074-16-4
2-bromophenylethyl alcohol

: 791814-79-4
methanesulfonic acid 2-[2-(6-{3-[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-propyl}-benzo[1,3]dioxol-5-yl)-phenyl]-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 72 percent / camphorsulfonic acid monohydrate / CH₂Cl₂ / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: trimethyl borate / tetrahydrofuran; hexane / 1.25 h / cooling

3.1: 77 percent / Pd(OAc)2; Ph₃P; aq. NaHCO₃ / dioxane / 12 h / Heating

4.1: 71 percent / tetrahexylammonium iodide; aq. NaOH / CH₂Cl₂

5.1: 88 percent / H₂ / Pd/C / methanol / 760 Torr

6.1: BH₃*SMe₂ / tetrahydrofuran

7.1: 0.79 g / CH₂Cl₂

8.1: 99 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With palladium diacetate; sodium hydroxide; n-butyllithium; dimethylsulfide borane complex; camphor-10-sulfonic acid; hydrogen; sodium hydrogencarbonate; tetrahexylammonium iodide; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; 3.1: Suzuki coupling;
DOI:10.1021/jo049157q