dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Base Information

Chemical Name:dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate
CAS No.:1435940-00-3
Molecular Formula:C₁₇H₁₉BrNO₃P
Molecular Weight:396.221
Hs Code.:

Synonyms:dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

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Chemical Property of dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

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Technology Process of dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

There total 3 articles about dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-(p-bromophenyl)tetrahydroisoquinoline

: 868-85-9
Dimethyl phosphite

: 1435940-00-3
dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Guidance literature:: With N-hydroxyphthalimide; cobalt(II) acetate hydrate; In acetonitrile; at 80 ℃; for 16h;
DOI:10.1021/acs.joc.8b00674

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1435940-00-3
dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium dihydrogenphosphate / isopropyl alcohol; ethylene glycol / 24 h / 85 - 90 °C / Schlenk technique; Inert atmosphere

2: cobalt(II) acetate hydrate; N-hydroxyphthalimide / acetonitrile / 16 h / 80 °C

With potassium dihydrogenphosphate; copper(l) iodide; N-hydroxyphthalimide; cobalt(II) acetate hydrate; In ethylene glycol; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.joc.8b00674

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1435940-00-3
dimethyl (2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium dihydrogenphosphate / isopropyl alcohol; ethylene glycol / 24 h / 85 - 90 °C / Schlenk technique; Inert atmosphere

2: cobalt(II) acetate hydrate; N-hydroxyphthalimide / acetonitrile / 16 h / 80 °C

With potassium dihydrogenphosphate; copper(l) iodide; N-hydroxyphthalimide; cobalt(II) acetate hydrate; In ethylene glycol; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.joc.8b00674