2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid
CAS No.:1233248-07-1
Molecular Formula:C₂₆H₁₈Cl₂N₂O₅
Molecular Weight:509.345
Hs Code.:

Synonyms:2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

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Chemical Property of 2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

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Technology Process of 2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

There total 12 articles about 2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: methyl (1-{[4-({[(3,4-dichlorobenzyl)oxy]carbonyl}amino)phenyl]carbonyl}isoquinolin-4-yl) acetate

: 1233248-07-1
2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 1233249-36-9
methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

: 1233248-07-1
2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydroxide / methanol / 18 h / 20 - 35 °C

2: oxalyl dichloride / chloroform / 3.5 h / 0 - 20 °C

3: tetrahydrofuran; acetonitrile; dichloromethane / 2 h / 0 °C

4: water; silver(I) acetate / 1,4-dioxane / 0.5 h / 60 °C

5: methanol; dichloromethane / 0.5 h / 20 °C

6: trifluoroacetic acid / chloroform / 1.5 h / 0 - 20 °C

7: pyridine / chloroform / 1 h / 0 - 20 °C

8: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 8 h / Reflux

9: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With pyridine; oxalyl dichloride; water; silver(I) acetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; acetonitrile; 4: |Wolff Rearrangement;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 1233249-37-0
1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

: 1233248-07-1
2-[1-[4-[(3,4-dichlorophenyl)methoxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: oxalyl dichloride / chloroform / 3.5 h / 0 - 20 °C

2: tetrahydrofuran; acetonitrile; dichloromethane / 2 h / 0 °C

3: water; silver(I) acetate / 1,4-dioxane / 0.5 h / 60 °C

4: methanol; dichloromethane / 0.5 h / 20 °C

5: trifluoroacetic acid / chloroform / 1.5 h / 0 - 20 °C

6: pyridine / chloroform / 1 h / 0 - 20 °C

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 8 h / Reflux

8: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With pyridine; oxalyl dichloride; water; silver(I) acetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; acetonitrile; 3: |Wolff Rearrangement;
DOI:10.1016/j.bmc.2013.10.025