2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

Base Information

Chemical Name:2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol
CAS No.:1363394-56-2
Molecular Formula:C₂₄H₂₄BrNO₅S
Molecular Weight:518.428
Hs Code.:

Synonyms:2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

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Technology Process of 2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

There total 12 articles about 2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1363394-55-1
4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

: 1363394-56-2
2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

Guidance literature:: With N-Bromosuccinimide; C₃₂H₁₉N₂O₈P; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ol300180w

Reference yield: 89.0%

: 1363394-55-1
4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

: 1363394-56-2
2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

: 1363394-61-9
C₂₄H₂₃Br₂NO₅S

Guidance literature:: With N-Bromosuccinimide; C₃₂H₂₁O₄P; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ol300180w

Reference yield:

: 1363394-48-2
methyl 2,3-dimethoxy-6-(trifluoromethylsulfonyloxy)benzoate

: 1363394-56-2
2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol

Guidance literature:: Multi-step reaction with 7 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; triethylamine / acetonitrile / 48 h / 20 °C / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

3: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

4: manganese(IV) oxide / toluene / 12 h / 20 °C / Reflux

5: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 24 h / 20 °C / Reflux

6: boron trichloride / hexane; dichloromethane / 2 h / -10 °C

7: N-Bromosuccinimide; C₃₂H₂₁O₄P / dichloromethane / 1 h / 0 °C

With manganese(IV) oxide; N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; C₃₂H₂₁O₄P; palladium 10% on activated carbon; hydrogen; boron trichloride; tetra-(n-butyl)ammonium iodide; triethylamine; scandium tris(trifluoromethanesulfonate); In methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/ol300180w