Technology Process of 3-(3-bromo-4-methoxyphenyl)-7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline
There total 12 articles about 3-(3-bromo-4-methoxyphenyl)-7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1.5h;
DOI:10.1021/ol300180w
- Guidance literature:
-
Multi-step reaction with 8 steps
1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetra-(n-butyl)ammonium iodide; triethylamine / acetonitrile / 48 h / 20 °C / Reflux
2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr
3: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere
4: manganese(IV) oxide / toluene / 12 h / 20 °C / Reflux
5: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 24 h / 20 °C / Reflux
6: boron trichloride / hexane; dichloromethane / 2 h / -10 °C
7: N-Bromosuccinimide; C32H21O4P / dichloromethane / 1 h / 0 °C
8: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C
With
manganese(IV) oxide; N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); C32H21O4P; palladium 10% on activated carbon; hydrogen; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; scandium tris(trifluoromethanesulfonate);
In
methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ol300180w
- Guidance literature:
-
Multi-step reaction with 4 steps
1: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 24 h / 20 °C / Reflux
2: boron trichloride / hexane; dichloromethane / 2 h / -10 °C
3: N-Bromosuccinimide; C32H21O4P / dichloromethane / 1 h / 0 °C
4: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C
With
N-Bromosuccinimide; C32H21O4P; boron trichloride; sodium hydride; scandium tris(trifluoromethanesulfonate);
In
hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ol300180w
