S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate

Base Information

Chemical Name:S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate
CAS No.:1433017-70-9
Molecular Formula:C₁₇H₁₉BrClNO₄S
Molecular Weight:448.765
Hs Code.:

Synonyms:S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate

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Chemical Property of S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate

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Technology Process of S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate

There total 4 articles about S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1433016-21-7
(S)-3-((2S,3R)-3-(4-bromophenyl)thiirane-2-carbonyl)-4-isopropyloxazolidin-2-one

: 75-36-5
acetyl chloride

: 1433017-70-9
S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate

: 1433017-79-8
C₁₇H₁₉BrClNO₄S

Guidance literature:: With cobalt(II) chloride; In dichloromethane; at 0 - 20 ℃; regiospecific reaction; Inert atmosphere;
DOI:10.1002/anie.201204771

Reference yield:

: 1433014-73-3
(S)-2-diazo-1-(4-isopropyl-2-thioxooxazolidin-3-yl)ethanone

: 1433017-70-9
S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate

: 1433017-79-8
C₁₇H₁₉BrClNO₄S

Guidance literature:: Multi-step reaction with 2 steps

1: dirhodium(II) tetraacetate dihydrate / dichloromethane / -20 °C / Inert atmosphere

2: cobalt(II) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With dirhodium(II) tetraacetate dihydrate; cobalt(II) chloride; In dichloromethane;
DOI:10.1002/anie.201204771

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1433017-70-9
S-((1R,2S)-1-(4-bromophenyl)-1-chloro-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropan-2-yl) ethanethioate

: 1433017-79-8
C₁₇H₁₉BrClNO₄S

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / ethanol / 0.5 h / 0 - 50 °C / Inert atmosphere

2.1: N,N-dimethyl-aniline / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 0.67 h / 0 - 20 °C / Inert atmosphere

3.1: dirhodium(II) tetraacetate dihydrate / dichloromethane / -20 °C / Inert atmosphere

4.1: cobalt(II) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With dirhodium(II) tetraacetate dihydrate; potassium carbonate; N,N-dimethyl-aniline; cobalt(II) chloride; In ethanol; dichloromethane;
DOI:10.1002/anie.201204771