Technology Process of N-(4′-methoxyphenyl)-6-methyl-3-carboxamidocoumarin
There total 4 articles about N-(4′-methoxyphenyl)-6-methyl-3-carboxamidocoumarin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-methyl-2-oxo-2H-chromene-3-carboxylic acid;
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
Inert atmosphere;
4-methoxy-aniline;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/mrc.4541
- Guidance literature:
-
Multi-step reaction with 3 steps
1: piperidine / ethanol / Reflux
2: sodium hydroxide / ethanol; water / 4 h / Reflux
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 0 - 20 °C
With
piperidine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
ethanol; dichloromethane; water;
1: |Knoevenagel Condensation;
DOI:10.1039/c6ra05262b
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / ethanol; water / 4 h / Reflux
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 0 - 20 °C
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
ethanol; dichloromethane; water;
DOI:10.1039/c6ra05262b
