FPA 138

Base Information

• Chemical Name: FPA 138
• CAS No.: 106869-10-7
• Molecular Formula: C₁₇H₁₃N₃O
• Molecular Weight: 275.31
• Mol file: 106869-10-7.mol

Synonyms:FPA 138

Chemical Property of FPA 138

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FPA 138

There total 5 articles about FPA 138 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

quinoline 2-carbaldehyde (5470-96-2) + benzoic acid hydrazide (613-94-5) → benzoic acid (quinolin-2-yl)methylenehydrazide (106869-10-7)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.1039/C6RA00993J

Reference yield: 89.0%

quinoline 2-carbaldehyde (5470-96-2) + benzoic acid hydrazide (613-94-5) → FPA 138 (106869-10-7)

Guidance literature:

With acetic acid; In methanol; for 4h; Reflux;

DOI:10.1016/j.molstruc.2010.03.016

Reference yield:

2-methylquinoline (91-63-4) → benzoic acid (quinolin-2-yl)methylenehydrazide (106869-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: selenium(IV) oxide / 1,4-dioxane / 12 h / 80 °C

2: acetic acid / ethanol / Reflux

With selenium(IV) oxide; acetic acid; In 1,4-dioxane; ethanol;

DOI:10.1039/C6RA00993J

upstream raw materials:

quinoline 2-carbaldehyde

benzoic acid hydrazide

benzoic acid methyl ester

benzoic acid

Downstream raw materials:

2-phenyl-5-(quinolin-2-yl)-1,3,4-oxadiazole

[Mn(quinoline-2-carbaldehyde benzoyl hydrazone)Cl₂]

Refernces

• 1、 Biswas, Niladri,Saha, Sandeepta,Biswas, Barun Kumar,Chowdhury, Manas,Rahaman, Ashikur,Junghare, Vivek,Mohapatra, Swati,Hazra, Saugata,Zangrando, Ennio,Roy Choudhury, Ruma,Roy Choudhury, Chirantan. "The DNA- and protein-binding properties and cytotoxicity of a new copper(II) hydrazone Schiff base complex". . p. 1482 - 1504. Retrieved 2021.
• 2、 Sheeja,Mangalam, Neema Ani,Prathapachandra Kurup,Sheena Mary,Raju,Varghese, Hema Tresa,Panicker, C. Yohannan. "Vibrational spectroscopic studies and computational study of quinoline-2-carbaldehyde benzoyl hydrazone". . p. 36 - 46. Retrieved 2010.
• 3、 Shang, Zhi-Hao,Sun, Ji-Na,Guo, Jiang-Shan,Sun, Yuan-Yuan,Weng, Wei-Zhao,Zhang, Zhen-Xiao,Li, Zeng-Jing,Zhu, Yan-Ping. "Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides". . . Retrieved 2020/01/08.